METRIC & METRIC Extended Follow-up

The METRIC study has been completed, and the results are publicly available from the Lancet Gastroenterology and Hepatology website here.

Thank you to all patients, investigators and collaborators.

The METRIC study (Magnetic resonance Enterography or ulTRasound In Crohn's disease) was designed to compare the diagnostic accuracy of MRI and ultrasound in Crohn’s disease. Two distinct cohorts of patients were recruited: (1) patients with a new diagnosis of Crohn’s disease, and (2) patients with known Crohn’s disease, presenting with a flare of activity.

This multicenter prospective cohort study was developed by a group of BSGAR and BSG-affiliated sites, led by Professor Stuart Taylor from University College London. It was funded by the Health Technology Assessment programme of the National Institute for Health Research.

Primary objective:

To compare diagnostic accuracies of MRI and Ultrasound Scanning for the detection of small bowel Crohn’s disease, and grading of inflammatory activity.

Sensitivity for each test will be measured against a consensus reference standard. This means that the results from any other tests, all of which are tests that are commonly used to detect and diagnose Crohn’s disease, will be collated in order to provide a comparison for the Ultrasound and MRI results. The other tests include other types of imaging, as well as investigations (for example, blood tests) and examinations.

Recruitment

Recruitment to METRIC has closed.

METRIC Extended Follow-up (METRIC-EF)

METRIC-EF is an extension to the METRIC study, funded by the NIHR Health Technology Assessment Programme (HTA). The new study aims to determine if imaging abnormalities at the diagnosis of Crohn’s Disease (CD) can help predict which patients will go on to develop more severe CD after 5 years. 

The study will use the existing METRIC recruitment sites, and is co-led by Stuart Taylor and Andrew Plumb from UCL.

If you have questions about the METRIC study, please contact the METRIC Team at the following address:

METRIC Study Team
The Comprehensive Clinical Trials Unit at UCL
University College London
Gower Street
London WC1E 6BT
email: CCTU-enquiries@ucl.ac.uk